Zinc-chelated imidazole groups for DNA polyion complex formation.

نویسندگان

  • Shoichiro Asayama
  • Satoshi Nishinohara
  • Hiroyoshi Kawakami
چکیده

This communication presents the pH-dependent chelation of Zn(2+) ions with the imidazole groups of poly(1-vinylimidazole) (PVIm) and DNA polyion complex formation with the zinc-chelated PVIm (PVIm-Zn) via chelated Zn(2+) ions. The resulting PVIm-Zn/DNA complexes exhibit no significant cytotoxicity and show outstanding gene expression.

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عنوان ژورنال:
  • Metallomics : integrated biometal science

دوره 3 7  شماره 

صفحات  -

تاریخ انتشار 2011